Dr. Anindyajit Banerjee

Head of Bioinformatics

As the Head of Bioinformatics at Karkinos Healthcare Pvt. Ltd., Dr. Anindyajit’s professional interests are focused on understanding the genomic landscape of the Indian cancer cohort. His research involves analysing data derived from Whole Genome Sequencing, Targeted Gene Panel Sequencing, and Whole Transcriptomic Sequencing to understand the genomic and transcriptomic alterations that lead to different clinical outcomes in Indian cancer patients. He has experience in analyzing next-generation sequencing data of paediatric acute lymphoblastic leukaemia (ALL) and identifying somatic copy number variations, single nucleotide variations, fusion detection, and gene expression alterations. His goal is to use computational genomic approaches to provide uniform treatment opportunities for patients based on their genetic profiles. During his doctoral training, his research interests were focused on different arms of computational biology like structural biology, network biology, and whole genome analysis.

RESEARCH INTEREST

Computational Genomics

  • Whole genome sequencing
  • Targeted Exome sequencing
  • Whole Transcriptomic analysis

Computational Structural Biology

  • Protein structure prediction
  • Molecular Docking studies
  • High throughput screening of small molecules
  • Molecular Dynamics studies

Sequence Analysis

  • Identification of the important network nodes
  • Node path analysis
  • Pathway analysis

PEER-REVIEWED PUBLICATIONS (as First author)

  1. Banerjee A, Dey S, Chakraborty A, Datta A, Basu A, Chakrabarti S and Datta S. . 2014) Binding mode analysis of a major T3SS translocator protein PopB with its chaperone PcrH from Pseudomonas aeruginosa Proteins, 82(12):3273-85.
  2. Ahmad B, Banerjee A, Tiwari H, Jana S, Bose S, Chakrabarti S. (2018)Structural and functional characterization of the Vindoline biosynthesis pathway enzymes of Catharanthus roseus. Journal of Molecular Modeling, 24:53.
  3. Das S, Banerjee A, Ali N, Chakrabarti S. (2020) A chemical inhibitor of heat shock protein 78 (HSP78) from Leishmania donovani represents a potential anti-leishmanial drug candidate Journal of Biological Chemistry (Accepted, May 2020)

PEER-REVIEWED PUBLICATIONS (as Co-author)

  1. Das M, Banerjee A, Sarkar S, Majumder J, Chakrabarti S, Jana S. (2020) Amino-alcohol Bioconjugate of Naproxen Exhibits Anti-inflammatory Activity through NF-κB Signaling Pathway. bioRxiv (doi: https://doi.org/10.1101/2020.01.10.901223)
  2. Shadab M, Banerjee A, Sinha R, Das S, Asad M, Kamran M., Maji M, Deepthi M, Jha B, Kumar M, Tripathi A, Kumar B, Chakrabarti S, Ali N. (2019) RNA-seq revealed expression of many novel genes associated with Leishmania donovani persistence and clearance in the host macrophage. Frontiers in Cellular and Infection Microbiology.
  3. Palit S, Mukherjee S, Niyogi S, Banerjee A, Patra D, Chakraborty A, Chakrabarti S, Chakrabarti P, Dutta S. (2018) Quinoline-Glycomimetic Conjugates Reducing Lipogenesis and Lipid Accumulation in Hepatocytes. Chembiochem. Jun 13.
  4. Chauhan J, Dasgupta M, Luthra T, Awasthi A, Tripathy S, Banerjee A, Paul S, Nag D, Chakrabarti S, Chakrabarti G, Sen S. (2018) Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO). Eur J Pharm Sci. Aug 28.
  5. Bhattacharyya D, Hazra S, Banerjee A, Datta R, Kumar D, Chakrabarti S, and Chattopadhyay S. (2016) Transcriptome-wide identification and characterization of CAD isoforms specific for podophyllotoxin biosynthesis from Podophyllum hexandrum. Plant Mol Biol.;92(1-2):1-23.
  6. Chanda SD, Banerjee A, Nandi S, Chakrabarti S, Sarkar MC. (2015) Cordycepin an Adenosine Analogue Executes Anti Rotaviral Effect by Stimulating Induction of Type I Interferon. J Virol Antivir Res; 4:2.
  7. Paul A, Samaddar S, Bhattacharya A, Banerjee A, Das A, Chakrabarti S, DasGupta M. (2014) Gatekeeper tyrosine phosphorylation is autoinhibitory for Symbiosis Receptor Kinase. FEBS Lett, 588(17):2881-9.
  8. Goyal M, Alam A, Iqbal MS, Dey S, Bindu S, Pal C, Banerjee A, Chakrabarti S, Bandyopadhyay U. (2012) Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum. Nucleic Acids Res, 40(3):1174-90.